Three regions of the brain are the key components in the development and persistence of substance use disorders: the basal ganglia, the extended amygdala, and the prefrontal cortex. Prolonged, repeated misuse of substances can produce changes to the brain that can lead to a substance use disorder.

Chronic substance use disorders significantly impact individuals, families, communities, and society. Substance use disorders (SUD) occur when the recurrent use of alcohol and/or drugs causes clinically significant impairment, including health problems, disability, and failure to meet major responsibilities at work…

substance — psychoactive compound with the potential to cause health and social problems, including substance use disorder. brain — the key components in the development and persistence of substance use disorders: the basal ganglia, the extended amygdala, and the prefrontal cortex. alcohol use disorder (AUD) — chronic medical condition that is categorized by difficulty stopping or controlling alcohol use, and by using alcohol to relieve or avoid withdrawal symptoms, even when it is…. drug diversion — when medication is redirected from its intended destination for personal use, sale, or distribution to others; includes drug theft, use, or tampering (adulteration or substitution).